Abstract
Objective: The present study aimed to investigate the dyslipidemic effects of risperidone, clozapine, andhaloperidol while teaching first-episode schizophrenia.Place and Time: The sample (n=340) was selected from the outpatient department of the Sir Cows Jee Jehangir Institute of Psychiatry Hyderabad (CJIP). The selected patients were randomly grouped (100 each) to receiverisperidone, clozapine and haloperidol and 40 were given placebo (multivitamin). This study was single blinded.The duration of study was 3 months (April to June 2011)Results: The Mean, Standard Deviation and SEM values of risperidone was in total cholesterol level 207.2 ±44.90 , 4.49, in HDL level 40.1 ± 6.60, .660, in LDL level 154.3 ± 28.64, 2.86,. and in triglyceride level 179.7 ±37.07 , 3.70, Chi-squire test was used to compare the total cholesterol of control group and cholesterol level afterrisperidone 0.001 P value was<.005 highly significantConclusion: Patients with severe mental illnesses are at increased metabolic risk. Psychiatric medications canincrease metabolic risk. Treatment decisions have implications for metabolic risk and outcomes.Key Words: Psychosis, Risperidone, Clozapine, Haloperidol, Placebo, Hyperlipidemia.
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