Prevalence Study of Urinary Tract Pathogens in the Patients from a Tertiary Hospital in Bangladesh

Abstract

Hospitalizations due to urinary tract infections are among the most commonly observed condition throughout the world. The study conducted among a total of 200 positive urine samples comprising male and female patients of different age showed E. coli (120), Klebsiella spp. (56) and Proteus spp. (24). Based on antibiotic susceptibility testing, It was revealed that E. coli showed lowest resistance to cefotaxime (35%) and highest resistance to levofloxacin (60%), whereas, Klebsiella spp. showed resistance to ceftriaxone (30.59%) and amoxicillin (88.33%). Likewise, Proteus spp. observed to have 29.16% (azithromycin) and 70.83% (ciprofloxacin) resistance. Cefotaxime was found to be the best drug for the treatment of E. coli related infections with 66.67% sensitivity. Ceftriaxone (69.41%) sensitive) was also found to be the best drug for the treatment of Klebsiella spp., whereas Proteus spp. could be effectively treated by Azithromycin (70.83% sensitive). Thirty-six (36) Multi drug resistant (MDR) pathogens were found in the sample of the elder males, 29 MDR pathogens were found in the sample of young males, 39 MDR were found in the sample of young females, and 40 MDR were found in the sample of elder females. Sixty eight percent of the isolated strains were highly multidrug resistant. Overall, MDR prevalence was 72%, and E. coli exhibited 54.16% MDR prevalence among isolates. The results revealed a surge in MDR pathogens that could impose major threat among community health.