Abstract
BackgroundSalmonella is one of the main causative agents of diarrhea which results in substantial disease burden. To determine the prevalence, serotype distribution, and antimicrobial resistance profiles of clinical Salmonella isolates in Shenzhen, a 6-year surveillance study was conducted.ResultsA total of 297 (5.7%) Salmonella strains were isolated from stool samples from 5239 patients. Among the 42 serotypes identified, serotype Typhimurium was the most common one which represented 39.7% of the isolates (118), followed by serotype Enteritidis (71, 23.9%), London (12, 4.0%), 4, 5, 12: i: - (11, 3.7%), and Senftenberg (8, 2.7%). A high frequency of resistance was found in ampicillin (70.6%), piperacillin (64.5%), tetracycline (63.5%), and streptomycin (54.3%). Resistance to ampicillin and tetracycline was observed in 95.3% of S. Typhimurium isolates; and nalidixic acid in 93.1% of S. Enteritidis isolates. Resistance to 5 or more antimicrobial agents was found in 78.8% of S. Typhimurium and 69.0% of S. Enteritidis isolates. A decreased susceptibility to ciprofloxacin and levofloxacin was associated with amino acid alteration in gyrA gene. Point mutations without amino acid changes were seen in gyrB, parC, and parE genes.ConclusionsA broad range of serotypes are responsible for Salmonellosis in Shenzhen, with Enteritidis and Typhimurium being the most common serotypes. The high level of antibiotic resistance is of public health significance and ongoing monitoring combined with rational use of antibiotics are recommended. Point mutations in gyrA gene might play an important role in the resistance to fluoroquinolones.
Highlights
Salmonella is one of the main causative agents of diarrhea which results in substantial disease burden
To improve our understanding of the prevalence of Salmonella in this region and provide basis for designing prevention and control strategies, we investigated the serotypes and antibiotic resistance of the isolates obtained from the surveillance network during 2013 and 2018
3870, 425, and 944 cases were enrolled from Peking University Shenzhen Hospital (PKUSZH), Shenzhen Children’s Hospital (SCH), and The Eighth Affiliated Hospital (SYSU8H), respectively
Summary
Salmonella is one of the main causative agents of diarrhea which results in substantial disease burden. Serotype distribution, and antimicrobial resistance profiles of clinical Salmonella isolates in Shenzhen, a 6-year surveillance study was conducted. Salmonella is a main foodborne and waterborne pathogen worldwide which causes an annual death of 230,000 [1]. Salmonella-associated foodborne outbreaks were transmitted by contaminated food such as beef, pork, tomato, and cucumbers [2,3,4,5]. It was prevalent throughout the year, but was the most commonly detected between. Salmonella isolates with different serotypes vary in the pathogenicity, prevalence, and sensitivity to antibiotics. Some serotypes were reported in only single region of the world, such as
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