Abstract
BackgroundBotulism is a severe neuroparalytic disease caused by toxins produced by several Clostridium species. This work presents the surveillance results of botulism in Iran, with the distribution of the cases by regions and by vehicle of transmission.MethodsWe describe the findings of the Centers for Disease Control and Prevention (CDC) surveillance on 2037 suspected cases of food-borne botulism during 2007–2017.ResultsA total of 252 (12.3%) cases were confirmed to food-borne botulism. The mean annual incidence per 100,000 Iranian Natives was 7.1 cases for male individuals and 3.3 cases for female individuals. All botulism events were confirmed to be foodborne. The most commonly implicated food was home-prepared traditional processed fish product, followed by the consumption of commercially canned products and non-pasteurized dairy products. Forty-eight (19%) fatal botulism were reported which, the case-fatality rate declined from 4.5% to 0.7% during the study period.ConclusionLaboratory-based diagnosis of botulism is an imperative procedure to elucidate cases, particularly food-borne botulism, to identify toxins in food and confirm clinical diagnosis, helping sanitary control measures. In addition, educational materials related to botulism prevention should be disseminated to different communities.
Highlights
Botulism, a potentially fatal neuroparalytic disease, is caused by highly potent neurotoxins produced by the Gram-positive, anaerobic spore-forming bacteria, Clostridium botulinum, Clostridium barati, Clostridium butyricum, Clostridium sporogenes and Clostridium argentinense [1,2]
Botulinum Neurotoxin (BoNT) blocks evoked quantal acetylcholine release from motor ending at all peripheral cholinergic synapses, producing a profound but transient muscle flaccid paralysis [4]
A severe case of botulism leads to death of the patient due to paralysis of the respiratory muscles [5]
Summary
A potentially fatal neuroparalytic disease, is caused by highly potent neurotoxins produced by the Gram-positive, anaerobic spore-forming bacteria, Clostridium botulinum, Clostridium barati, Clostridium butyricum, Clostridium sporogenes and Clostridium argentinense [1,2]. A severe case of botulism leads to death of the patient due to paralysis of the respiratory muscles [5]. Clostridium botulinum produce botulinum toxin under specific conditions that incorporate an anaerobic, low-acid and -salt environment. Home-preserved foods regularly achieve these conditions, and present a high risk for botulism. Botulism is a severe neuroparalytic disease caused by toxins produced by several Clostridium species. This work presents the surveillance results of botulism in Iran, with the distribution of the cases by regions and by vehicle of transmission
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