Prevalence Rates of Personality Disorder and Its Association With Methamphetamine Dependence in Compulsory Treatment Facilities in China.

Chenxi Zhang,Liang Liu,Wei Hao,Tao Luo,Huixi Dong

doi:10.3389/fpsyt.2018.00698

Abstract

Methamphetamine use is popular and rapidly increasing in China, and the co-occurrence of personality disorders has an impact on treatment outcomes and may increase vulnerability of developing dependence. The aim of the present study was to investigate the prevalence rates of personality disorders in methamphetamine users and further explore the association between personality disorders and methamphetamine use status. Five hundred and seventy-seven male methamphetamine users were recruited. The self-developed questionnaire was used for demographics, and a Structural Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) (SCID-I/II) was performed covering psychiatric diagnosis. Our study found the prevalence of antisocial personality disorder in male methamphetamine users was 71.4%, followed by borderline (20.2%) and obsessive-compulsive (17.9%) personality disorder. Borderline and antisocial personality disorders were found to be risk factors of methamphetamine dependence (adjusted odds ratio = 2.891, p = 0.007 and adjusted odds ratio = 1.680, p = 0.042). These findings suggested personality disorders were highly prevalent in male methamphetamine users, and the comorbidity of antisocial and borderline personality disorders are especially associated with methamphetamine dependence.

Highlights

Novel psychoactive substances (NPS) are synthetic substances that have been developed to produce altered states of consciousness and perceptions
Five hundred and twenty-five male MA users were analyzed in the study
The MA users suffered from affective disorder (26.1%), followed by psychotic disorder (20.2%), and anxiety disorder (7.2%)

Summary

Introduction

Novel psychoactive substances (NPS) are synthetic substances that have been developed to produce altered states of consciousness and perceptions. The use of NPS has harmful outcomes on both physical and neuropsychiatric symptoms including respiratory depression, cardiac arrest or multiple organ failure [1]. Other symptoms of NPS include sedation and loss of consciousness, to bizarre repeated motions, to erratic running [3]. As one of the most commonly known NPS [4], Methamphetamine (MA) has become the second-most prevalent used drug around the Personality Disorder in Methamphetamine Users world [5]. In China, the recreational use of MA is increasing and does not show signs of decreasing [5]. In the year 2016, the MArelated seizures reached 29 tons and more than half of the newly reported drug users were MA users in China [6]

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