Abstract
Polycystic ovarian syndrome (PCOS) is a most common endocrinopathy in women of reproductive age group characterised by various metabolic and reproductive disturbances. Vitamin D is a fat-soluble vitamin having major influence on reproductive health. The beneficial effects of vitamin D on reproduction may be attributed to ovulation stimulation as well as improved implantation. Since infertility is the frequent presentation in patients with PCOS, we aim to determine the circulating vitamin D levels in infertile patients with PCOS in comparison with normal fertile controls and to correlate it with other endocrine parameters. A cross sectional study was conducted in a tertiary care hospital including 111 infertile patients presenting with PCOS and 107 normal fertile controls in the age group 18-39yrs. Circulating FSH, LH, Total testosterone, SHBG (sex hormone binding globulin) and vitamin D levels were measured in both the groups by chemiluminescence immunoassay. Free androgen index (FAI) was calculated. Circulating vitamin D levels in PCOS patients was compared with normal fertile controls using unpaired ‘t’ test and correlated with other endocrine parameters like FSH, LH, Testosterone, SHBG and FAI using Pearson correlation analysis. Mean circulating vitamin D levels in cases were significantly lower compared to controls (17.08 Vs 26.95, p<0.001). Vitamin D showed a significant negative correlation with testosterone (r -0.66, p<0.001), FAI (r -0.41, p<0.001) and significant positive correlation with SHBG (r 0.18, p< 0.001). No significant correlation was observed between circulating vitamin D levels with other endocrine parameters like FSH, LH and LH:FSH ratio. Low circulating vitamin D levels in infertile PCOS patients and its correlation with endocrine parameters found in our study suggest the possible role of this fat-soluble vitamin in pathogenesis and complications of PCOS.
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