Prevalence of Urinary tract infection by multidrug resistant bacteria with special interest in extended spectrum beta lactamase producer in an urban hospital of Dhaka

Abstract

Urinary tract infections (UTIs) caused by extended-spectrum beta lactamase (ESBL)-producing bacteria have become a growing problem worldwide. The aim of this study was to investigate the clinical and radiological findings in patients with community-acquired UTIs owing to ESBL-producing bacteria. Database of the patients that had UTI owing to ESBL-producing bacteria were evaluated. Urine samples were collected from UTIsuspected patients attended at Apollo Hospital in Dhaka. A total of 4210 OPD-patients and 2067 IPD-patients database were included in the study. Mid stream urine was collected and processed for culture. A total of 1222 isolates were found in UTI patients attended the hospital from January to June 2012, of which 404 isolates were ESBL positive. Among the ESBL isolates, E. coli (80%) and Klebsiella spp. (12%) were found to be the most prevalent organism in UTI patients. There was a temporal influx of ESBL containing bacteria associated UTI found in February and May in both IPD and OPD patients. Females are more vulnerable to ESBL infection than male. The patients of above 46 years were found to be relatively more vulnerable than the youth age group. Children below 15 years of age also have higher incidence of UTI. UTIs owing to ESBL-producing bacteria begin to replace UTIs owing to non-ESBL-producing bacteria. Thus, our future aim should be to evaluate the predisposing factors behind the fact to prevent infections owing to ESBL-producing bacteria.