Abstract
In infancy most common and a serious disease is known as Urinary tract infection (UTI). The aim of the current study is to evaluate the frequency and antibiotic resistant among infant presenting with UTI in Lahore General hospital, Lahore-Pakistan. The current observational study comprised 100 (n=100) cases diagnosed with UTI. The study was conducted at Lahore General Hospital, Pakistan, between March 2019 and January 2020. Data were collected and recorded on specified proformas that had information on demographics, biochemical analysis, and complaints, as well as the antibiotic used and blood cultures. The most common gram-negative bacilli (GNB) causing UTI was E. coli constitute about 72% followed by Klebsiella (11%), Enterobacter (7%) and Enterococcus (4%). Most of the isolated pathogens are highly resistant to ampicillin, cotrimoxazole, and cephalexin (72%–95%), have intermediate sensitivity to third- generation cephalosporins, and high sensitivity to amikacin, nitrofurantoin and ciprofloxacin. Similarly, the other pathogens showed different degree of occurrence and resistance against empirically used antibiotics. The most prevalent UTI causative organism among children was E. coli. The insulated microorganisms were highly resistant to ampicillin, and highly sensitive to amikacin.
Highlights
In infancy Urinary tract infection (UTI) is one of the critical illnesses
Most of the isolated pathogens are highly resistant to ampicillin, cotrimoxazole, and cephalexin (72%–95%), have intermediate sensitivity to third- generation cephalosporins, and high sensitivity to amikacin, nitrofurantoin and ciprofloxacin
The aim of this study was to assess clinical presentations and outcomes, and in particular antimicrobial resistance in infants and children hospitalized with UTI at the Lahore General Hospital, Pakistan
Summary
In infancy Urinary tract infection (UTI) is one of the critical illnesses. It is a bacterial infection mostly seen in admitting infant and a leading cause of hospitalization in children. Untreated UTI leads to life threatening conditions like renal failure and other complications. UTI occurs mainly in the first year of life for boys, much more often among uncircumcised boys. The prevalence of UTI differs by age. In the first year of life, the relationship between males and females is between 2.8 and 5.4, respectively. Over the age of 1 to 2, there is a striking female predominance with a male-female ratio of 1:10
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