Prevalence of the Genus Propionibacterium in Primary and Persistent Endodontic Lesions: A Systematic Review.

Mario Dioguardi,Vito Crincoli,Enrica Laneve,Lorenzo Lo Muzio,Giancarlo Malagnino,Cristian Quarta,Giuseppe Troiano,Diego Sovereto,Lucio Lo Russo,Riccardo Aiuto,Mario Alovisi

doi:10.3390/jcm9030739

Abstract

Propionibacterium are anaerobic/aero-tolerant rod Gram-positive bacteria, and numerous studies are associated with primary and secondary endodontic infections. The data in the literature on the prevalence of Propionibacterium are conflicting, and there are studies that report conflicting data on the prevalence in primary and secondary endodontic infections. This review aims to clarify the prevalence of bacteria of the genus Propionibacterium in endodontic lesions. The present systematic review work was performed on the basis of the Prisma protocol. A search was carried out on the PubMed and Scopus databases with the use of keywords. The research produced 410 records, which, after the elimination of the overlaps and the application of the inclusion and exclusion criteria, led to a number of 36 included articles divided by the three outcomes. The first outcome concerns prevalence of bacteria of the genus Propionibacterium in primary and secondary endodontic lesions. The secondary outcome, differences in the prevalence of bacteria of the genus Propionibacterium between primary endodontic infections and secondary endodontic infections. The tertiary outcome, differences in the prevalence of Propionibacterium Acnes compared to Propionibacterium propionicum in endodontic infections. The results of the meta-analysis show that the genus Propionibacterium bacteria are more prevalent in secondary endodontic infections and that P. acnes has a higher prevalence than P. propionicum.

Highlights

The bacteria involved in primary endodontic lesions are mainly aerobic and facultative anaerobes
This review aims to clarify the prevalence of bacteria of the genus Propionibacterium in endodontic lesions
The results of the meta-analysis show that the genus Propionibacterium bacteria are more prevalent in secondary endodontic infections and that P. acnes has a higher prevalence than P. propionicum

Summary

Introduction

The bacteria involved in primary endodontic lesions are mainly aerobic and facultative anaerobes. For persistent intraradicular and extraradicular secondary infections, the scientific literature focuses on the role of the enterococci (enterococcus faecalisis) of streptococci (Gram-positive optional anaerobic bacteria) while calling into question the role of bacteria of the genus Actinomyces and of the genus Propionibacterium for persistent infections involving the extraradicular apical surface with the formation of bacterial biofilms. Propionibacterium are anaerobic/aerotolerant rod Gram-positive bacteria, and numerous studies are associated with primary and secondary endodontic infections; the prevalence data are conflicting. The latest review conducted by Prada et al, 2019 on the role of bacteria in endodontic infections did not perform meta-analysis on the prevalence of Propionibacterium [6]

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