PREVALENCE OF SICK EUTHYROID SYNDROME IN NON-THYROIDAL ILLNESS

Abstract

INTRODUCTION: Sick euthyroid syndrome is also known as low triiodothyronine (T3) syndrome or non-thyroidal illness syndrome which is characterized by alterations in the levels of thyroid hormones in the absence of any disorder related to thyroid gland or hypothalamic-hypophysial axis. Abnormal findings on thyroid functions tests which occur in the setting of a non thyroidal illness (NTI) without preexisting hypothalamic-pituitary and thyroid gland dysfunction. In the 1970s initially described low T3 (triiodothyronine) syndrome, known as the euthyroid sick syndrome or the nonthyroidal illness syndrome (NTIS). This can be representing especially in in critically ill patients, particularly those admitted to intensive care units. Although by definition these abnormalities are not related to intrinsic diseases of hypothalamus-pituitary-thyroid axis though rather represent imbalances in thyroid hormone production, metabolism, and action. As there is progress in illness gradual development of a more complex syndrome associated with low levels of T3 and thyroxine (T4). AIM: The main objective of this study is to study clinical profile sick euthyroid syndrome in Non-thyroidal Illness. MATERIAL AND METHODS: Total 60 patients were included in this study with the diagnosis of euthyroid syndrome with suggestive of Non-thyroidal Illness. From all the patients detail history were recorded as data as well as all the necessary lab investigations were recorded as hemogram, renal function test, liver function test, ECG, Chest roentgenogram, and thyroid function status and serum cholrine esterase. RESULT: Total 60 patients were including in this study within the period of study with different age group. Patients with age group 20-30 years age group shows majority followed by age group 30-40 years age group as 33.3% and 30% respectively. Among the 60 patients only 15 patients were observed as sick Euthyroid. Out of 15 patients with sick Euthyroid 60% showed Low T3 alone and 40% shows changes in T3, T4 & TSH Levels. CONCLUSION: Non-thyroidal illness syndrome is common among male in comparisons to female with the middle ages. Since the mechanism of sick euthyroid syndrome is similar to sick euthyroid syndrome in other critical care illnesses. Therefore more and more studies should be done for the better evaluation of the prognostic value of NTIS in critically ill. Thyroid functions should be assessed routinely in patients for prevent of Non-thyroidal illness syndrome. 
 KEYWORDS: sick euthyroid syndrome, Non-thyroidal Illness, Thyroid