PREVALENCE OF RISK FACTORS AND TARGET ORGAN DAMAGE CAUSED BY HYPERTENSION IN RESIDENTS OF THE ARAL SEA REGION OF UZBEKISTAN

Abstract

Objective: Analysis of the results of screening the population over 40 years of age for early detection of risk factors and target organ damage caused by hypertension in real clinical practice of family clinics in the Aral Sea region. Design and method: The results of screening of 2430 respondents were analyzed according to the modified PEN WHO protocol, which 1020 people with blood pressure (BP) 140/90 mm Hg or more included in the study. The average age was 57.68±8.06 years, women 61.4%, men 38.6%. Additionally, we determined echocardiography, ultrasound examination of the brachiocephalic arteries, microalbuminuria, creatinine and uric acid in blood serum. Statistical data are presented as M±SD. Results: Among the patients with high BP, 24 (2.4%) were under 40 years old, 847 (81%) were aged 40-65 years, 169 (16.6%) were over 65 years old. Obesity was detected in 46.2% of patients, left ventricular hypertrophy in 96%, microalbuminuria in 76%, proteinuria in 21%, thickening of the intima-media of the common carotid artery >0.9 mm in 92% of the examined. It was revealed that low cardiovascular risk was 2 times more common among women compared to men: 11.3% versus 5.6% (χ2=8.990; p=0.003); almost 4 times fewer patients with coronary artery disease: 7.4% versus 28.9% (χ2=14.939; p=0.0001); there are no tobacco users or regular alcohol drinkers, whereas among men these risk factors were identified in 59.4% (χ2=178.848; p=0.0001) and 35% (χ2=82.238; p=0.0001), respectively. Hyperuricemia prevailed in men compared to women: 23.3% versus 6.4% (χ2=60.243; p=0.0001) but the incidence of type 2 diabetes is 2 times higher in women compared to men: 13.7% versus 7.4% (χ2=9.205; p=0.002) Conclusions: The study showed a wide distribution of CVD risk factors among the hypertensive population of the Aral Sea region and significant target organ damage caused by hypertension. Among hypertensive men, there was a significant prevalence of tobacco and alcohol use, a significantly frequent detection of coronary artery disease, and hyperuricemia compared to women; type 2 diabetes mellitus is significantly more frequently detected in the female population.