Prevalence of renal artery stenosis in hypertensive type II diabetic subjects

Abstract

men and women, women in menopause, patients with hypertension, type 2 diabetes, dyslipidemia, men and women with positive or negative angiography findings, young survivors of myocardial infarction and their family members, and patients examined before and after treatment with ciprofibrate. The analysis revealed an excelent positive correlation between FERHDt_ and the logarithmically transformed ratio of TG/HDL-C [LOGTG/HDL-C) in all cohorts. This index, which we propose to call atherogenicity index (LAI} ranged from average -0.240 in girls' cord plasma to 0.611 in men with type 2 diabetes mellitus. Women and children had average values of LAI lower than zero. Postmenopausal women had higher LAI (0.112) than premenopausal women (-0.084). Female had lower LAI than their male counterparts in all cohorts. In men with hyperlipidemia the treatment with ciprofibrate decreased the LAI from 0.546 to 0.276. Patients with positive angiography findings had higher LAI (men 0.315, women 0.287) than those with negative findings (men 0.196, women 0.0111. LAI apparently reflects the lipoprotein particle size which is essentially influenced by the concentration and relative content of TG and HDL-C. As the LAI ranges from negative (-J to positive (+) values it is easy to differentiate between atherogenic and nonatherogenic lipoprotein profiles of plasma. LAI equal to zero corresponded to LDL particles diameter of 25.3