Prevalence of pre-diabetes and cardio-metabolic risk factors in first degree relatives of patients with type-II DM

Abstract

Background: It is evident that first degree relatives (FDRs) of people with type 2 diabetes are at greater cardiovascular and diabetes risk. The present study was conducted to assess prevalence of pre-diabetes and cardio-metabolic risk factors in first degree relatives of patients with type-II diabetes mellitus. Materials & Methods: 80 first degree relatives of patients suffering from Type 2 DM of both genders were included. Parameters such as fasting lipid profile, fasting blood sugar (FBS), post prandial blood sugar (PPBS), glycated haemoglobin (HbA1c) was recorded. Results: Out 80 patients, males were 50 and females were 30. Age group 30-34 years had prediabetics seen in 7, 35-39 years in 10, 40-44 years in 8 and 45-49 years in 10. Diabetes was absent in 10 in age group 30-34 years, 12 in age group 35-39 years, 11 in age group 40-44 years and 12 in age group 45-49 years. The mean value in subjects with absent diabetes and present diabetes of BMI (kg/m2) was 23.5 and 26.2, FBS (mg/dl) was 92.8 and 112.4 and HbA1c (%) was 5.1 and 5.9, LDL (mg/dl) was 128.2 and 148.2, HDL (mg/dl) was 43.8 and 35.7, TG (mg/dl) was 132.5 and 152.4 respectively. The difference was significant (P< 0.05). Conclusion: There was high prevalence of prediabetes and other cardio metabolic risk factors in first degree relatives of patients with type 2 DM patients