PREVAlENCE OF POTENTIAllY ADVERSE DRUG-DRUG INTERACTIONS IN HOSPITAlS OF WEST KAZAKHSTAN

Abstract

Consequences of medical drugs use have been a subject of scientific research, both in terms of long-term effect on the gene pool of populations and immediate effects on human health. Drug-drug interactions (DDI) is an important and still insufficiently recognized cause of medical errors and costs for the healthcare system. We have studied the prevalence and structure of DDI in hospitals of West Kazakhstan. We performed a retrospective analysis of pharmacotherapy in a systematic sample of 730 patients with cardiovascular diseases treated in the hospitals of Aktobe, Uralsk, Atyrau cities in 2014. Potentially dangerous DDI were identified using Drug Interaction Checker source (FDA). The prevalence of major and moderate potential DDI and their structure were studied. Associations between DDI and other studied variables were estimated using odds ratios (OR) and chi-squared tests. For all estimates 95 % confidence intervals (CI) were calculated. We found a high prevalence of major and moderate DDI (53,8 (95 % CI 50,9-58,3) % and 88,1 (95 % CI 85,590,3) %, respectively. We found out that 53,8 % of patients were treated with at least one potentially inappropriate combination. The effect of age (OR 1,8, p 0,001, 95 % CI 1,4-2,5) and polypragmasy (OR 6,0, р 0,001, 95 % CI 2,7-13,1) on potentially dangerous DDI were revealed. Adverse drug effects were diagnosed in 4,1 % of patients, they were more frequently observed in patients with more prescriptions (р = 0,001). The most frequent drugs creating a dangerous combination were spironolactone, ACE inhibitors, enoxaparinm sodium, fondaparinux sodium, clopidogrel, potassium chloride, sartana.