Prevalence of Post-Traumatic Stress Disorder after the Great East Japan Earthquake in Patients with Cardiovascular Diseases -The CHART-2 Study-

Abstract

Possible role of brain natriuretic peptide (BNP) as a biomarker for risk stratification in the general population has received attention. However, determinants of plasma BNP level in apparently healthy subjects remains unclear. Here we addressed this issue by analysis of data in the Tanno-Sobetsu Study. Of 638 study participants in 2008, 369 subjects were randomly selected for determination of plasma BNP and adiponectin and urine 8-hydrodeoxyguanosine (8-OHdG). We excluded subjects on medication and data from 199 subjects (60.9613.1 y/o, 45% male) were used for the analysis. Plasma BNP level was 18.9619.2(SD) pg/ml. In univariate analysis, plasma BNP was significantly correlated with age (r 5 0.37), body mass index (BMI), systolic (r 5 0.28) and diastolic (r 5 0.20) blood pressure, adiponectin (r 5 0.42), urine albumin-to-creatine (Cr) ratio (r 5 0.20), urine sodium-to-Cr ratio and V1S+V5R voltage. In stepwise multiple logistic analysis, age, BMI, diastolic pressure, plasma adiponectin, urine albuminto-Cr ratio and urine 8-OHdG-to-Cr ratio were shown to be independent predictors of BNP level, and the model explained 31% variation of plasma BNP. Plasma adiponectin and urine 8-OHdG levels were positive and negative predictors, respectively, suggesting that their responses are secondary to change in plasma BNP. The present results indicate that age, blood pressure and renal factor reflected by urine albumin are primary determinants of plasma BNP level in apparently healthy subjects.