Abstract
Objective: The current research evaluated the prevalence of pernicious anemia (PA) in patients with macrocytic anemia (high MCV) and low serum B12 in Riyadh. Methods: Blood testing was done in 77 patients (males: 45.5%, females: 54.5%) with macrocytic anemia; 84 patients; (males: 23.8%, females: 76.2%) with low serum B12 and 30 healthy subjects. Complete blood count, differential count, folic acid, vitamin B12, intrinsic factor, gastric parietal cell antibodies and holotranscobalamin II were assessed. Results: A total of five subjects from 161 patients had PA; three of these patients had macrocyticanemia (3.90%) and two patients had low serum B12 (2.38%). Significant differences (p<0.05) in some hematological, immunological, biochemical parameters were found in subjects with macrocytic anemia and low serum B12 compared to controls. Conclusions: Pernicious anemia in patients with macrocytic anemia and low serum B12 was for the selected sample size can be assumed to be uncommon in Riyadh, Saudi Arabia.
Highlights
Pernicious anemia (PA) is a chronic illness where body fails to produce normal healthy red blood corpuscles (RBCs) because of deficiency of vitamin B12 required for normal cell growth.[1,2,3] The deficiency of Vitamin B12 occurs because of reduced dietary intake or impaired absorption due to lack1
The present study evaluated the incidence of pernicious anemia (PA) in patients with macrocytic anemia and in patients with low serum B12
There was no significant difference in haematological and biochemical parameters between males and females in patients with macrocytic anemia
Summary
Pernicious anemia (PA) is a chronic illness where body fails to produce normal healthy red blood corpuscles (RBCs) because of deficiency of vitamin B12 required for normal cell growth.[1,2,3] The deficiency of Vitamin B12 occurs because of reduced dietary intake or impaired absorption due to lack. Al-Gahtani FH, MD, College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia. 1-3: College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia Al-Gahtani FH, MD, College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia. 1-3: College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
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