PREVALENCE OF OVERLAP SYNDROME AND ITS CORRELATION WITH VARIOUS COMORBIDITIES IN COPD PATIENTS ADMITTED IN A TERTIARY CARE HOSPITAL: A COHORT STUDY

Abstract

Introduction:Theoverlapsyndromewas first coinedbyDavidC.Flenley in1985 todescribethecoexistenceofobstructive sleep apnoea (OSA) in patients with chronic obstructive pulmonary disease (COPD). Patients with Overlap Syndrome experience more profound nocturnal oxygen desaturation (NOD) than patients with OSA or COPD alone. Little is known about the possible predictors of the overlap syndrome and its association with comorbidities contributing to impaired outcome.Objectives:This study aimed to evaluate the prevalence and possible predictors of the overlap syndrome and its correlation with various comorbidities in a cohort of COPD patients.Materials & Methods:Individuals with COPD (GOLD, riskgroupsA–D) admittedinourhospitalfromMarch2021 toDecember 2021.Informationonage,gender,bodymass index (BMI), waist-hip ratio, smoking status, Adjusted neck circumference Epworth sleepiness scale (ESS),STOP BANG, COPD assessment test score,comorbidities,was collectedanda spirometry wasperformed.Participants underwent Level 1 sleep study in our hospital.An apnoea-hypopnea index (AHI) >5 per hour was considered to indicate OSA. Results:Around 50 patients were enrolled with a mean age of 60.7 of whom male is 52 % and female is 48%. During nocturnal polysomnography, 39.1% had evidence of OSA.AHI had statisticaly correlated with Diabetes,Hypertension (p value<0.005).Also in our study we found AHI had statisticaly correlated between ESS score and severity of COPD (GOLD Class B & C)(p value<0.005).Pulmonary Arterial Hypertension and Diabetes were more common in patients with overlap syndrome. Conclusion: The prevalence of COPD patients with OSA is 24%. BMI and smoking history seems to be a predictoroftheoverlapsyndrome.Thesepatientsmaybemoreaffectedbypulmonaryarterialhypertensionanddiabetes