Prevalence of Obesity-Related Glomerulopathy in Morbidly Obese Patients at Cairo University Tertiary Hospital

Abstract

BACKGROUND: Obesity has been reported to be a risk factor for chronic kidney disease and albuminuria. Obesity-related glomerulopathy (ORG) usually has a gradual onset, with microalbuminuria or clinically dominant proteinuria as the primary manifestation, with or without impaired renal function, and a small number of patients manifesting with microscopic hematuria or nephrotic syndrome. AIM: The present study aimed to evaluate the prevalence of ORG in morbidly obese patients and its impact on renal function. PATIENTS AND METHODS: This is a descriptive cross-sectional study that included patients with morbid obesity who visited the bariatric clinic in our institution during the period from October 2019 to February 2021. Patients who had no history of diabetes mellitus (DM) or hypertension underwent blood pressure measurement, assessment for 24-h urinary albumin to detect patients with laboratory-based ORG, kidney function tests, urine analysis and HbA1c, and examination by abdominal sonogram focused on both kidneys. Patients with asymptomatic micro or macroalbuminuria were recruited to the study. RESULTS: The total number of patients screened during the study period was 1,045, out of whom 100 patients were eligible for the study according to the inclusion and exclusion criteria, denoting an albuminuria prevalence of 9.5% and there is no statistically significant relationship between this albuminuria and age, gender, and BMI. CONCLUSION: ORG is a rising problem in the field of morbid obesity management, the current study shows that the prevalence of ORG is 9.5% in our screened cohort.