Prevalence of neuropathy in patients with type 2 diabetes in Iran : Asystematic review and meta-analysis.

Abstract

Diabetic neuropathy is one of the most common complications of diabetes, which leads to amputation and significant disability in patients. Studies conducted in this field show different prevalences and inconsistencies in the country. This study attempts to determine the overall prevalence of neuropathy in patients with type2diabetes in Iran with ameta-analysis. The present study was conducted using a meta-analysis method from January 2000 to December 2018. The papers related to the study subject were obtained from searching Scopus, ScienceDirect, Magiran, Barakat Knowledge Network, SID, Medline (PubMed), and Google Scholar databases. The heterogeneity of studies was examined using I2index and the data were analyzed using the software Comprehensive Meta-Analysis (version3, Biostat, Englewood, NJ, USA). The results of the systematic review showed regional differences in the prevalence of neuropathy in Iran. According to the meta-analysis and review of 10studies and 2992individuals between the ages of 5years and 86years, the overall prevalence of neuropathy in type2 diabetes patients in Iran was 56.5% (95% confidence interval, CI 42.8-69.3%). The highest prevalence of neuropathy in type2 diabetic patients was found in Mashhad with 87.2% (95% CI 77.9-92.3%) in 2012 and the lowest prevalence of neuropathy in type2 diabetic patients was found in Ahvaz with 22.7% (95% CI 18.5-27.6%) in 2014. With the increase in years of research, the prevalence of neuropathy in type2diabetes in Iran was reduced, with statistically significant differences (P < 0.05). Considering the high prevalence of neuropathy in patients with type2diabetes in the country, it is essential that health policy makers take effective measures to reduce this disease in diabetes patients.