Prevalence of multidrug resistance bacterial isolates from infected wound patients in Dhaka, Bangladesh: A cross-sectional study

Abstract

IntroductionMultidrug resistance (MDR) is threatening the adequate coverage of antibiotics. This study aimed to analyze the antimicrobial resistance pattern of bacterial isolates from wound infection and the scenario of multidrug resistance. MethodsMicrobiological culture results scripts of Medinova Medical Services LTD, representing non-repetitive various wound samples (post-surgical, trauma, superficial skin, burn) reported between January 2017 and March 2018, were retrieved and analyzed for pathogens and their antimicrobial resistance patterns using R version 3.5.3. ResultsOverall, 1266 bacterial isolates were obtained, and 850 (67.1%) were identified as MDR. The percentage of MDR among gram-positive and gram-negative bacterial isolates were 68.8% and 66.0%, respectively. Among isolates Staphylococcus aureus (n = 401), Pseudomonas aeruginosa (n = 200), and Escherichia coli (n = 193) were predominant. Vancomycin followed linezolid showed most activity against gram-positive bacteria. Whereas, Colistin was found to be the most active against most of the gram-negative bacterium except for the Proteus spp in sensitivity test. Although, carbapenem group was determined to be the best against Proteus spp. About 82% Enterococcus spp and 76% Proteus spp were MDR. Isolates from patients aged >60 years (AOR = 1.774 95%CI: 1.089–2.892) were more prone to becoming MDR in compared to other age group and was a significant determinant (P = 0.02) of MDR. ConclusionsOur study revealed that the presence of MDR pathogens in wound infection was noteworthy. The findings of this study would assist in decision making of wound infection treatment.