Abstract
Background: Rheumatoid arthritis is most common inflammatory arthritis. Methotrexate is backbone of treatment regimens. Objective: To determine the prevalence of Methotrexate intolerance in rheumatoid arthritis. Material and Methods: 150 patients of RA including 120 females and 30 males attending rheumatology services of hospital from December 2012 to December 2015 were prescribed MTX as per approved protocol and were followed for Methotrexate Intolerance Severity Score (MISS). Results: Out of 150 patients of RA on methotrexate (MTX), 21 (14%) were found to have MISS ≥ 6. Conclusion: MISS is an important tool for application in RA to know Methotrexate intolerance and timely intervention to mitigate the same in order to prevent the incompliance of an otherwise very effective DMARD for RA.
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