Abstract
AbstractBackgroundMild behavioral impairment (MBI) is a neurobehavioral syndrome characterized by later life emergence of neuropsychiatric symptoms. Our previous meta‐analysis showed that the pooled prevalence of MBI among cognitively normal (CN), subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) subjects are 17%, 35.8% and 45.5% respectively. The main aim of this study is to calculate the pooled prevalence of MBI subdomains.MethodA search of the literature on MBI in MCI, CN, and SCI and CN but at risk (CN‐AR) subjects published between 1 January 2003 and 14 January 2021 was conducted. Meta‐analysis using a random effects model was performed to determine the pooled estimate of the prevalence of MBI subdomains. Meta‐regression was performed to identify factors contributing to the variance of prevalence rate.ResultNine studies conducted among 11568 subjects (9259 CN, 1057 SCI & 1252 MCI) with retrievable subdomain data underwent meta‐analysis, revealing pooled prevalence of affective dysregulation (AFD), impulse dyscontrol (IDS), decreased motivation (DMT), social inappropriateness (SIP) and abnormal perception/ thought (APT) of 31.2% (95% CI 24.6‐38.5%), 27.9% (95% CI 22.2‐34.6%), 11.5% (95% CI 7‐g18.5%), 7.4% (95% CI 4.1‐12.9%), and 3.4% (95% CI 1.7‐6.7%) respectively. Although all subdomains demonstrate ordinal increase in pooled prevalence from CN, SCI and MCI subgroups, meta‐regression demonstrated no significant difference in subdomains prevalence among cognitive subgroups. The pooled prevalence of AFD and IDS are greater than that of SIP and APT among all cognitive subgroups. Among MCI subjects, racial group (Asian vs. Caucasians) could account for variance between the studies in prevalence of IDS (coefficient 1.5908, 95% CI 0.7850‐2.3966, R2 analogue 0.63, p<0.001).ConclusionAFD and IDS are two most prevalent MBI subdomains and remain the same with cognitive deterioration. This finding is potentially relevant to clinical practice.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
