Abstract
Introduction: Methylphenidate is a neuropsychotropic agent, indicated for the treatment of Attention Deficit / Hyperactivity Disorder (ADHD) and narcolepsy, and is commonly prescribed for school and university age patients. The growing prescription of the drug and the misuse of methylphenidate by academics without a diagnosis of ADHD and / or narcolepsy have raised concerns on the part of medical societies of psychiatry. The over-the-counter use of this substance causes potential dependence and adverse effects such as hallucinations, anxiety, dry mouth and visual disturbances. Unfortunately, there is a precarious amount of epidemiological data on the use of methylphenidate without prescription by university students. In view of this reality. Objectives: The present study proposed to review the assessment of the prevalence of methylphenidate consumption without medical prescription in university environments worldwide, with sources published between 2016-2021. Methods: To perform this research, the PubMed (https://pubmed.ncbi. nlm.nih.gov/) and Scielo (https://www.scielo.org/) databases were used as a search tool, using the Key words “non-medical”, “methylphenidate” and “university students”. Results: So far, 10 articles related to the study (carried out in China, Australia, Brazil, South Africa, Iran, Israel, Pakistan and the United States) have been identified, with 8 articles obtained from PubMed and 2 articles acquired from Scielo. The selected articles show that in 6 of these articles the groups of academics studied were undergraduate and graduate students in general areas, and 4 articles in medical students. The studies present cases of students who confirmed the use of methylphenidate without a prescription, with the justification that it improves academic performance even in healthy students. Conclusion: Therefore, further studies on epidemiology and effects on academic performance with the improper consumption of this drug are recommended.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
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