Abstract
Background:The dramatic increase in the prevalence of methicillin-resistantStaphylococcus aureusas a source of nosocomial and community-associated infections in Saudi Arabia has attracted the attention of many researchers and public health workers. Hence, the aim of this meta-analysis is to assess the extent of the problem in Saudi Arabia at large.Methodology:PubMed database was searched for articles about the prevalence of MRSA in Saudi Arabia, and the relevant data from all eligible studies were analyzed to assess the overall prevalence rate by ProMeta3.Results:Seven articles were included in this meta-analysis with the sample size of 8433 individual. The overall prevalence of MRSA was 38% (95% CI: 28 – 50). The prevalence of MRSA according to the region was 32% (95%CI: 21 – 46) for the central region and 42% (95% CI: 33 – 52) for the western region.Conclusion:The findings of this study indicate that the overall prevalence of MRSA in Saudi Arabia is relatively high, with the western region showing the highest prevalence rates, which necessitates the urgent implementation of preventive and educative strategies.
Highlights
Antibiotic resistance of a significant number of bacterial pathogens has emerged as a growing public health threat, attracting the attention of many health organizations, as it hinders the efforts of effectively preventing and treating the increased bacterial infections [1]
The prevalence of Methicillin-Resistant Staphylococcus Aureus (MRSA) according to the region was 32% (95%CI: 21 – 46) for the central region and 42% for the western region
The findings of this study indicate that the overall prevalence of MRSA in Saudi Arabia is relatively high, with the western region showing the highest prevalence rates, which necessitates the urgent implementation of preventive and educative strategies
Summary
Antibiotic resistance of a significant number of bacterial pathogens has emerged as a growing public health threat, attracting the attention of many health organizations, as it hinders the efforts of effectively preventing and treating the increased bacterial infections [1]. The Open Public Health Journal, 2018, Volume 11 585 method, by the mid of the twentieth century, the bacteria had already developed resistance to the drug by producing beta-lactamase enzyme which inactivates penicillin, ampicillin, and amoxicillin This necessitated the production of beta-lactamase stable antibiotics such as methicillin and cloxacillin [1]. In the early sixties of the last century, the first Methicillin-Resistant Staphylococcus Aureus (MRSA) was identified [8], initially, as a HospitalAcquired (HA-MRSA), and later, Community-Acquired (CA- MRSA) started to emerge and dramatically increase in number in many countries [1] Both asymptomatic and opportunistic forms of MRSA were reported in animals, though they occur transiently, they present a potential source of community-acquired infection [9]. The aim of this meta-analysis is to assess the extent of the problem in Saudi Arabia at large
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