Abstract
A total of 39 non-duplicate isolates of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter species isolated from blood and endotracheal secretions were tested for metallo-β-lactamase (MBL) production by modified-EDTA disc synergy and double disc synergy tests. The prevalence of MBLs was 33.33% by both the above tests. All patients with MBL-positive isolates were multidrug resistant and had multiple risk factors like > 8 days hospital stay, catheterization, IV lines, previous antibiotic use, etc. These were risk factors for imipenem resistance also. The overall mortality in MBL-positive patients was 46.15%.
Highlights
A total of 39 non-duplicate isolates of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter species isolated from blood and endotracheal secretions were tested for metallo- -lactamase (MBL) production by modified-ethylenediamine tetra-acetic acid (EDTA) disc synergy and double disc synergy tests.The prevalence of MBLs was 33.33% by both the above tests
The present study was conducted to determine the prevalence of MBLs in P. aeruginosa and Acinetobacter species in intensive care areas
All MBL-positive isolates were resistant to all the antibiotics tested
Summary
A total of 39 non-duplicate isolates of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter species isolated from blood and endotracheal secretions were tested for metallo- -lactamase (MBL) production by modified-EDTA disc synergy and double disc synergy tests.The prevalence of MBLs was 33.33% by both the above tests. [1] The first plasmid-mediated MBL was reported in Pseudomonas aeruginosa in Japan in 1991.[2] Since many countries including few reports from India are available regarding the prevalence of MBLs.[3,4,5,6,7,8] The present study was conducted to determine the prevalence of MBLs in P. aeruginosa and Acinetobacter species in intensive care areas.
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