Abstract
Introduction: Metabolic syndrome as one of the risk factors for cardiovascular diseases has recently been the focus of clinical studies. This study was conducted to determine the prevalence of metabolic syndrome in hemodialysis patients in Iran. Methods: The present systematic review was done using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Case-control, cohort and crosssectional studies conducted in Iran were included. Clinical trials, case reports, letters to editors, systematic reviews, study protocols, narrative reviews, and case series were excluded. Subgroup analysis was conducted for determining the heterogeneity based on the participants as well as their gender. Meta-analysis was conducted using STATA version 14.0. Results: The prevalence of metabolic syndrome among 799 patients was 50% (95% CI: 47.0, 53.0, I2=50.6). The analysis of subgroups was conducted for determining the heterogeneity based on the participants as well as their gender. Based on the analysis of the subgroups using a random effects model, the prevalence of metabolic syndrome was found to be 44% and 55% in Iranian men and women undergoing hemodialysis, respectively. Conclusion: Given the high prevalence of metabolic syndrome in hemodialysis patients, it is advisable and logical that patients with chronic renal failure should be regularly evaluated for metabolic syndrome and cardiovascular risk factors both at the diagnosis time and afterwards.
Highlights
Metabolic syndrome as one of the risk factors for cardiovascular diseases has recently been the focus of clinical studies
Given the high prevalence of metabolic syndrome in hemodialysis patients, it is advisable and logical that patients with chronic renal failure should be regularly evaluated for metabolic syndrome and cardiovascular risk factors both at the diagnosis time and afterwards
Study Characteristics The studies were done on 799 kidney failure patients undergoing hemodialysis
Summary
Metabolic syndrome as one of the risk factors for cardiovascular diseases has recently been the focus of clinical studies. This study was conducted to determine the prevalence of metabolic syndrome in hemodialysis patients in Iran. Metabolic syndrome has recently been reported as a risk factor for cardiovascular diseases and became the focus of clinical studies.[1,2,3,4]. Metabolic syndrome includes the risk factors of diabetes and cardiovascular diseases including clinical findings such as low high-density lipoprotein (HDL-C) level, obesity, elevated triglyceride level, impaired glucose tolerance, and hypertension.[5] the main physiopathological cause of this syndrome is still unknown, the available evidence introduces insulin resistance as the main cause of metabolic disorders.[6] According to Adult Treatment Panel III (ATP III) criteria, the diagnosis of this syndrome is based on the presence of three or more of these symptoms.
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