Prevalence of mammary Paget\u2019s disease in urban China in 2016

Lu Xu,Shengfeng Wang,Pei Gao,Lili Liu,Zhenmin Zhao,Siyan Zhan,Guozhen Liu,Shilu Yin,Jinxi Wang,Jingnan Feng

doi:10.1038/s41598-021-82146-y

Abstract

No national data have been available on descriptive epidemiology of mammary Paget’s disease (MPD) in China. This population-based study aimed to estimate the prevalence of MPD and its pattens by sex, age and area in China. We conducted a population-based study using data in 2016 from China’s Urban Employee Basic Medical Insurance and Urban Resident Basic Medical Insurance, covering approximately 0.43 billion residents. MPD cases were identified based on the diagnostic names and codes in claim data. A total of 825 patients of confirmed diagnosis of MPD were found during the study period. The prevalence of MPD in 2016 was 0.42 per 100,000 population (95% CI 0.19 to 0.73), with marked female predominance. The prevalence rates peaked at 40–59 years and ≥ 80 years in females and males, respectively. The prevalence rates varied among different regions, ranging from 0.06 (95% CI 0.00 to 0.23) in Northeast China to 1.21 (95% CI 0.07 to 3.72) in Northwest China. MPD showed marked female predominance in China. Chinese female patients were much younger, with lower prevalence than that in the United States. Obvious sex difference in the age pattern of MPD prevalence was also observed in China.

Highlights

No national data have been available on descriptive epidemiology of mammary Paget’s disease (MPD) in China
The incidences of MPD were reported in two studies based on analysis of the Surveillance, Epidemiology, and End Results (SEER) database in the United States, which ranged from 0.44 per 100,000 woman-years to 1.31 per 100,000 woman-years between 1988 and 2 0119
As for the age trend of MPD prevalence, the prevalence peaked at 40–59 years old (1.63, 95% CI 0.72 to 2.90) among females, but among males, the prevalence kept rising with age, reaching the highest point at ≥ 80 years (0.75, 95% CI: 0.29 to 1.43)

Summary

Introduction

No national data have been available on descriptive epidemiology of mammary Paget’s disease (MPD) in China. This population-based study aimed to estimate the prevalence of MPD and its pattens by sex, age and area in China. Mammary Paget’s disease (MPD) is an uncommon clinical entity characterized by eczematous changes and ulceration, which usually affect the nipple or areola[1,2] It has different clinical presentations from other pathologic subtypes of breast cancer[3,4]. This study was conducted to provide recent estimates of the prevalence of MPD in mainland China and to investigate its patterns across sexes, age groups and geographical areas, using a nationally representative sample in 2016

Methods

Results

Conclusion