Prevalence of Low Bone Mass in Patients with Hemophilia and Its Related Ractors in Southern Iran

Abstract

Background: The previous studies reported conflicting outcomes concerning the prevalence and risk factors of low bone mass. The evaluation of bone mass and its related factors in patients with hemophilia in Southern Iran can help prevent osteoporosis and fracture amongst these patients. Objectives: The present study aimed to evaluate bone mass and its related factors in patients with hemophilia in Southern Iran. Methods: This study was conducted on 111 patients with hemophilia A and B. It assessed anthropometric data, sun exposure, puberty, physical activity, and mineral biochemical parameters. Bone mineral density (BMD) was measured via dual-energy X-ray absorptiometry (DXA). Statistical analysis was conducted by SPSS software V. 21. Results: The prevalence of low bone mass for chronological age (LBM) was 20.6% in the lumbar area and 23.7% in the femur. Low lumbar bone mass was merely associated with the severity of factor deficiency (P = 0.037, beta=0.896). Low femoral bone mass was associated with severity of factor deficiency (P = 0.022, beta = 0.939), BMI/BMI percentile (P = 0.013, beta = -0.181), HCV infection (P = 0.012, beta = 1.4), and weight (P = 0.002, Beta = -0.064). Conclusions: The prevalence of low bone mass was high in patients with hemophilia in southern Iran. The severity of the disease, HCV infection, and body mass index were the most relevant related factors.