Abstract
C Butters, LK Phuong, T Cole, A Gwee. JAMA Pediatrics . 2019;173(11):1084–1094 To perform a systematic literature review of the prevalence of primary immunodeficiency (PID) among pediatric patients with primary or recurrent invasive pneumococcal disease (IPD) and to identify factors associated with risk of PID diagnosis. Pediatric cases (18 years or younger) of primary or recurrent IPD from 17 studies (prospective, retrospective and case-control published between 1997 and 2018). The authors identified publications in PubMed, Embase, and Medline using standardized criteria (original data, 5 or more pediatric cases confirmed by isolation of Streptococcus pneumoniae from a sterile site via culture or polymerase …
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