Abstract
Background. Systemic lupus erythematosus (SLE) is a chronic inflammatory, multisystem, and autoimmune disease. Objective. The aim of this study was to describe the prevalence of hyposalivation in SLE patients and evaluate factors associated. Methods. This is a cross-sectional study developed at the Cuiaba University General Hospital (UNIC-HGU), Mato Grosso, Brazil. The study population consisted of female SLE patients treated at this hospital from 06/2010 to 12/2012. Unstimulated salivary flow rates (SFRs) were measured. Descriptive and inferential analyses were performed in all cases using a significance level P < 0.05. Results. The results showed that 79% of patients with systemic lupus erythematosus suffered from hyposalivation and that the disease activity and age in years were the factors that resulted in statistically significant differences. Conclusion. The activity of the disease, age >27 years, and the drugs used were factors associated with hyposalivation, resulting in a statistically significant decrease in saliva production.
Highlights
Systemic lupus erythematosus (SLE) is a systemic autoimmune and inflammatory disease that affects many organs and systems through formation and deposition of autoantibodies and immune complexes leading to severe tissue and organ damage [1, 2]
These two age groups showed that saliva decreased from less than 27 years to greater than 27 years, and this decrease was statistically significant (P = 0.021), as indicated by Student’s t-test
Few studies have been published in SLE patients [5,6,7,8,9,10,11, 13, 15,16,17] and the differences between these may be due to the differences in the diagnostic criteria of hyposalivation
Summary
Systemic lupus erythematosus (SLE) is a systemic autoimmune and inflammatory disease that affects many organs and systems through formation and deposition of autoantibodies and immune complexes leading to severe tissue and organ damage [1, 2]. Hyposalivation refers to a diminished salivary flow, whereas xerostomia refers to a subjective experience of mouth dryness This is further complicated by the fact that some patients. The results showed that 79% of patients with systemic lupus erythematosus suffered from hyposalivation and that the disease activity and age in years were the factors that resulted in statistically significant differences. The activity of the disease, age >27 years, and the drugs used were factors associated with hyposalivation, resulting in a statistically significant decrease in saliva production
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