Abstract
BackgroundThe infection with human papillomavirus (HPV) is the major cause of genital disease. This study assessed the prevalence and genotype of HPV among outpatient women and healthy women in Jiangsu, East China.MethodsA total of 65,613 women aged 16–85 years were recruited from Nanjing Kingmed Diagnostics, including 45,736 outpatients and 19,877 healthy women. The cervico-vaginal cells were collected and then HPV types were detected using the Tellgenplex™ HPV DNA Test.ResultsThe overall HPV prevalence was 17.7% for outpatients and 10.6% for healthy women. 13.7% outpatients were infected with a single HPV type and 4.0% were infected with multiple HPV types. Regarding healthy women, 8.5 and 2.1% were infected with single and multiple HPV types, respectively. The two most commonly detected HPV types were HPV 16 and 58 regardless of single- or multiple-type infection or source of the participants. HPV16 + 58 was the most commonly identified multiple genotype in outpatients, while HPV16 + 52 was frequently detected in healthy women. Highest prevalence rate was found in outpatients aged < 20 years and ≥ 60 years.ConclusionsThis study revealed the prevalence characteristics of HPV in both outpatient women and healthy women in Jiangsu province.
Highlights
The infection with human papillomavirus (HPV) is the major cause of genital disease
The overall prevalence of HPV infection In the 45,736 outpatient women, 8081 participants (17.7, 95% Confidence interval (CI): 17.3–18.0%) were infected with at least one HPV type, including 6253 participants (13.7, 95% confidence interval (95% CI): 13.4–14.0%) infected with a single HPV type and 1828 participants (4.0, 95% CI: 3.8–4.2%) infected with multiple HPV types (P < 0.001)
The HR-HPV prevalence rate (15.7, 95% CI: 15.3–16.0%) was higher than the LR/ Undetermined risk (UR)-HPV rate (7.4, 95% CI: 7.2–7.7%) (Table 1)
Summary
The infection with human papillomavirus (HPV) is the major cause of genital disease. The infection with human papillomavirus (HPV) is strongly associated with genital disease. Type-specific persistent infection with high-risk (HR) HPV is the major reason of cervical squamous intraepithelial lesions as well as cervical cancer [1,2,3]. According to its relationship with cervical cancer and precancerous lesions, HPV genotypes are divided into HR-HPV and low-risk (LR) HPV genotypes [4]. These different HPV genotypes have different pathogenicity [5]. The prevalence of HPV infection varies greatly by country, region within country, and population [8, 9].
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