Abstract
BackgroundPersistent infection with High Risk Human Papillomavirus (HR HPV) types plays a major role in the development of cervical cancer. Therefore, the detection of HR HPV types is an essential part of cervical cancer screening. The aim of this study was to estimate the prevalence of HR HPV infection among healthy women undergoing routine cervical cancer screening in Iran.MethodsIn this cross-sectional study, the results of HPV DNA typing in 2453 normal Iranian women who were referred for routine cervical cancer screening from September 2015 to March 2017 were analyzed. Participants were screened using COBAS assay for HPV DNA typing and liquid based cytology.ResultsA total of 2453 healthy sexually active women were included in this study. The mean age was 35.1 ± 8.08 years. The overall prevalence of HR HPV infection was 10.3%. HPV16 was found in 73 (3%) women. The prevalence of HPV18 and other HR HPV types were 16(0.7%) and166 (8.2%), respectively. Approximately, 5% of the study population had an abnormal cervical cytology (ASCUS or worse), of whom 34% were infected by HR HPV.ConclusionThe prevalence of HR HPV infection among Iranian women has increased in the recent years which indicates the need for public education and health planning to prevent this cancer through vaccination and early diagnosis using screening tests. HPV DNA typing, diagnosis and the distribution of prevalent genotypes should be considered in the development of comprehensive cervical cancer prevention programs in Iran.
Highlights
Persistent infection with High Risk Human Papillomavirus (HR human papilloma virus (HPV)) types plays a major role in the development of cervical cancer
It has been demonstrated that persistent infection with high risk human papilloma virus (HR HPV) types plays a major role in the development of cervical intraepithelial neoplasia and cervical cancer [2,3,4,5,6]
HPV DNA typing in clinical setting and the identification of HR-HPV genotypes is an important part of cervical cancer screening, as well as a means of providing valuable evidences necessary for the Jamdar et al Infectious Agents and Cancer (2018) 13:6 prevention and management of this cancer [11]
Summary
Persistent infection with High Risk Human Papillomavirus (HR HPV) types plays a major role in the development of cervical cancer. The aim of this study was to estimate the prevalence of HR HPV infection among healthy women undergoing routine cervical cancer screening in Iran. In the study by Khodakarami et al 2012, the prevalence of high-risk HPV infection in healthy women was 5.1% in Tehran, Iran and the HPV 16 was the most common detected virus genotype (17). HPV vaccination has been proven to offer near 100% protection against the development of cervical cancer and pre-cancerous lesion of HPV among individuals who have not previously been infected with HPV [11] Based on these results, HPV DNA typing in clinical setting and the identification of HR-HPV genotypes is an important part of cervical cancer screening, as well as a means of providing valuable evidences necessary for the Jamdar et al Infectious Agents and Cancer (2018) 13:6 prevention and management of this cancer [11]. The aim of this study was to estimate the prevalence of HR HPV infection among Iranian healthy women undergoing routine cervical cancer screening using COBAS HPV typing assay.
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