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Abstract
Human papillomavirus (HPV) infection is the main causes of cervical cancer in women worldwide. The goal of the present study was to determine the prevalence and distribution of HPV genotypes in women from Saudi Arabia. Recently, several HPV detection methods have been developed, each with different sensitivities and specificities. In this study, total forty cervical samples were subjected to polymerase chain reaction and hybridization to BioFilmChip microarray assessment. Human papillomavirus (HPV) infections were found in 43% of the specimens. The most prevalent genotypes were HPV 16 (30%) HPV 18 (8.0%) followed by type HPV 45, occurring at 5.0%. Our finding showed the HPV infection and prevalence is increasing at alarming rate in women of Saudi Arabia. There was no low risk infection detected in the tested samples. The BioFilmChip microarray detection system is highly accurate and suitable for detection of single and multiple infections, allowing rapid detection with less time-consumption and easier performance as compared with other methods.
Highlights
Cervical cancer is the second most prevalent disease worldwide occurrence with new cases every year and approximately 80% of them reported in developing countries (Munoz et al, 2003; Parkin and Bray, 2006; Lin et al, 2008; Chen et al, 2011 and 2012)
Detection and prevalence of Human papillomavirus (HPV) genotypes The most common HR-HPV types observed in this study were HPV 16, HPV 18 and HPV 45
Detection of HPV genotypes by BiofilmChip hybridization assay showed that the highest prevalence HPV 16 infection was found in the 35-76 year old age group and decreased slowly in older age groups in Saudi Arabian population and no other genotypes like HPV 31, 33, 35/68, 39/56, 51/59, 52/58, 6/11 were detected in all the screened samples (Table 1)
Summary
Cervical cancer is the second most prevalent disease worldwide occurrence with new cases every year and approximately 80% of them reported in developing countries (Munoz et al, 2003; Parkin and Bray, 2006; Lin et al, 2008; Chen et al, 2011 and 2012). Such type of cases appears mainly in between the age of 30 and 50. The BioFilmChip microarray detection system is highly accurate and suitable for detection of single and multiple infections, allowing rapid detection with less time-consumption and easier performance as compared with other methods
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