Prevalence Of HPV In Hospital Set Up And Its Correlation With CIN

Abstract

One hundred women were studied and the presence of high risk (HR) HPV infection was found in 12% women. On cytological examination, 17% women had normal smear, 49% inflammatory smear, 5% ASLVS, 16% LSIL, 5% HSIL, 4% Koilocytosis. Eight percent women who had HSIL in cervical cytology were HR HPV positive and 50% who had koilocytosis in Pap smear were HPV positive. All the HPV positive cases (30%) in the LSIL group were less than 30 years suggesting high prevalence of transient infection in this age group. HSIL cases were 30 years or above in age and 80% HPV positive cases in the HSIL group were also above 30 years. After age 30, a positive DNA test correlated well with cervical disease and represented a persistent infection. So screening programs for cervical cancer should use tests for HPV in women 30 years of age or older. Colposcopy was done in 70% patients. HPV positivity went on increasing with increasing grades of colposcopic cases; 60% HPV positivity was noted with grade III changes and 100% positivity with findings suggestive of malignancy. The correlation between histopathology (colposcopic directed biopsy) and HPV DNA testing suggested a strong association between HPV positivity with higher grades of CIN. HPV positivity was 33.2% in CIN 2 cases; 75% in CIN 3 and 100% in cases diagnosed as carcinoma in situ.