Prevalence of high Risk Human Papilloma Viruses 16 and 18 (HR-HPV16&18) Among Sudanese Patients with Esophageal Cancer

Abstract

Objective: The aim of this study was to screen for the presence of High Risk Human Papilloma Viruses 16 and 18 (HR-HPV16&18) among Sudanese patients with esophageal cancer. Methodology: The study was retrospectively examined 100 formalin fixed paraffin wax embedded tissue’s blocks for the presence of HR-HPV subtypes 16 and 18 by Immunohistochemical methods. All samples were previously obtained from Sudanese patients with esophageal cancer. Results: Regarding IHC staining for HPV 16 and 18, positive findings were revealed in 13 (13%) and couldn’t be disclosed in 88 (87%) of the study subjects, hence, none of the cases was identified with HPV18. Conclusion: HR-HPV subtype 16 is strongly contributed to the etiology of esophageal carcinoma in Sudan. Urgent preventive strategies are highly recommended to reduce the burden of esophageal cancer in Sudan.