Abstract
Hemorrhagic fever with renal syndrome (HFRS) was considered to be transmitted by Apodemus agrarius and Rattus norvegicus, the principal animal hosts of Hantaan virus and Seoul virus, respectively. The aim of this study is to determine the correlation of HFRS incidence with capture rate and hantavirus infection rate of rodent species in Qingdao City, China. We collected HFRS patients’ information and captured field and residential rodents in Qingdao City, China from 2010 to 2014. The correlations of HFRS incidence to rodent capture rate and hantavirus infection rate of rodents were analyzed statistically. The main findings of this study are that the high HFRS incidence (19.3/100,000) is correlated to the capture rate of field Mus musculus (p = 0.011, r = 0.037); but surprisingly it did not correlated to the capture rate of the principal rodent hosts Apodemus agrarius and Rattus norvegicus and the hantavirus infection rate of these rodent species in the field or residential area. These novel findings suggest that Mus musculus, a nontraditional animal host of hantavirus may play an important role in hantavirus transmission in Qingdao City.
Highlights
Hantavirus infections occur worldwide, but approximately 90% of hemorrhagic fever with renal syndrome (HFRS) cases has been reported in China[1]
A low level of Hemorrhagic fever with renal syndrome (HFRS) prevalence occurred from January to September each year; a small peak of HFRS prevalence occurred in the spring and summer between April and June in some years; and a high peak of HFRS prevalence occurred each year between October and December (Fig. 2)
Previous studies indicated that the spring peek is caused by Seoul virus and the autumn peak is caused by Hantaan virus[3]
Summary
Hantavirus infections occur worldwide, but approximately 90% of hemorrhagic fever with renal syndrome (HFRS) cases has been reported in China[1]. During 2006–2012, a total of 77,558 HFRS cases have been reported in China with 866 deaths[2]. Qingdao City located in eastern China is one of multiple high incidence areas of HFRS in China[3]. In China, HFRS is caused by Hantaan virus (HTNV) and Seoul virus (SEOV)[4,5,6]. The principal rodent host of HTNV is the striped field mouse Apodemus agrarius, and the principal rodent host of SEOV is commensal rodent brown rat Rattus norvegicus[7,8]. The aim of this study is to determine the correlations of HFRS incidence to rodent species and to hantavirus infection rate in the rodent species in Qingdao City from 2010 to 2014
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