Prevalence of Hemoglobinopathies in Manipur

Abstract

Background : Hemoglobinopathies are the world wide prevalent monogenic genetic disorder affecting the structure, function, or production of hemoglobin with variable geographic distribution. In the southeast asia and Indian subcontinent, this has been considered as common disorder of blood posing a major genetic and public health problem. Materials and Methods: This is a Cross Sectional study conducted in the Department Of Physiology, Department Of Pathology, RIMS between Jan 2014 - Feb 2015. A total of 400 from Manipur were included in the study. Interlab Genio Instrument For Alkali and acid Hemoglobin Electrophoresis was used. Data Entry And Analysis Was Done Using SPSS Version-16. Approval Was Taken From The Rims Institutional Ethics Committee. Results: Among 400 of population surveyed 12.75% of the study population shows the presence of abnormal hemoglobin. 7% were found to be beta thalassaemia carrier, 0.5% homozygous thalassemia, 4% HbE trait, 1% Homozygous HbE, 0.25% Hereditary persistance of hemoglobin F Conclusion: High prevalence of hemoglobinopathies where Beta thalassaemia in heterozygous state occurred more frequent than other hemoglobinopathies. The study concludes that it is important to explore the hemoglobin variants in Manipur so that the carriers can be detected and the serious damage to the future generation can be prevented.