Prevalence of helminth infestation during pregnancy and its association with maternal anemia and low birth weight

Abstract

ObjectiveTo determine the prevalence of helminth infestation during pregnancy and the associated risks of adverse maternal and infant outcomes. MethodsA cross-sectional study of women with a singleton pregnancy of at least 34weeks was conducted at a teaching hospital in Benin City, Nigeria, between April 1 and September 30, 2010. Socioeconomic and clinical data were obtained. Stool samples were used to determine helminth infection. Birth weight was recorded at delivery. Multivariable analysis was used to assess the link between helminth infestation and maternal and perinatal outcomes. ResultsAmong 178 women, 31 (17.4%) had a helminth infestation (15 [8.4%] had ascariasis, 8 [4.5%] trichuriasis, and 25 [14.0%] hookworm infestation). Multivariate analysis found that helminth infestations was associated with maternal anemia (adjusted odds ratio 12.4; 95% confidence interval 4.2–36.3) and low birth weight (adjusted odds ratio 6.8; 95% confidence interval 2.1–21.9). ConclusionApproximately one in five women had a helminth infestation in the third trimester of pregnancy. Maternal helminth infestation significantly increased the risks of maternal anemia and low birth weight, indicating that routine administration of anthelminthic drugs during early pregnancy might improve perinatal outcomes.