Abstract
Helicobacter pylori (H. pylori) has a role in the multifactorial etiology of peptic ulcer disease. A link between H. pylori infection and duodenal ulcer disease is now established. Other contributing factors and their interaction with the organism may initiate the ulcerative process. The fact that eradication of H. pylori infection leads to a long-term cure in the majority of duodenal ulcer patients and the fact that the prevalence of infection is higher in ulcer patients than in the normal population are cogent arguments in favor of it being the primary cause of the ulceration. This study was under taken at the Department of surgery, Narayana medical college, Nellore from January 2007 to July 2008. A total of 150 patients with duodenal ulcers, gastric ulcers, antral gastritis, gastric carcinoma and dyspepsia of any kind were studied. Maximum number of cases were in the age group of 31 years to 50 years among both sexes and number of cases gradually decreased after 50 years of age in males and females. Males were more in number and male to female ratio is (2.75:1) approximately 3:1.
Highlights
Helicobacter pylori (H. pylori) has a role in the multifactorial etiology of peptic ulcer disease
Virulence factors are those that allow H. pylori to survive in the hostile environment of the gastric lumen which includes its spiral shape, motility, adaptive enzymes, proteins, and ability to adhere to gastric mucosal cells and mucus. [2]
H.pylori are found in the deep portions of the mucous gel coating the gastric mucosa or between mucous gel layer and apical surfaces of the gastric mucosal epithelial cells
Summary
Helicobacter pylori (H. pylori) has a role in the multifactorial etiology of peptic ulcer disease. [1] The role of H. pylori as a gastric pathogen is dependent on virulence factors and pathogenic mechanisms. H.pylori are found in the deep portions of the mucous gel coating the gastric mucosa or between mucous gel layer and apical surfaces of the gastric mucosal epithelial cells. They located in the regions of the tight junctions between adjacent mucosa epithelial cells. H.pylori infection reduces the levels of ascorbic acid in the gastric juice. Tobacco smoking increases the risk of duodenal ulceration for patient infected with H.pylori. Tobacco smoking increases the risk of duodenal ulceration for patient infected with H.pylori. [8]
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