Abstract
Endoscopic antral biopsies were obtained from 30 patients with several gastrointestinal disorders and analysed for the presence of H. pylori. This bacterium was present in 80% and 58%, respectively, of patients with either gastric and duodenal ulcers and gastric neoplasm. In none of the healthy individuals, H. pylori could be found. Another 14 patients with various diseases of the stomach, undergoing a major gastric resection, had been treated with 200 mg ciprofloxacin intravenously immediately before the operation. Blood and various tissues samples were taken during the operation. The prevalence of IgG antibodies against H. pylori in these patients was 93%. H. pylori could be determined in 71% of the cases by the urease production; by culture, this was possible in only one case. The mean peak concentration of ciprofloxacin in serum was 5.31 mg/l and 1.17 mg/l, respectively, immediately and 60 min after the end of infusion; in tissues of antrum and duodenum, 1.59 to 1.64 mg/kg and 1.41 to 1.72 mg/kg, respectively, 45-270 min after the infusion. The results show that ciprofloxacin rapidly penetrates into tissues and attains concentrations greater than the MIC90 for H. pylori. However, these concentrations can inhibit the isolation of this microorganism but not its urease activity. This fact could be interpreted by the existence of a nonculturable but metabolically active form of H. pylori. This would explain the high rate of recrudescence following most types of currently applied therapeutic schemes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Zentralblatt für Bakteriologie : medical microbiology, virology, parasitology, infectious diseases
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.