Abstract
Background and objective: This study was performed to evaluate the prevalence of Hepatitis C virus (HCV) infection as well as HBV, HDV, HTLV I/II, and HIV infection in hemodialysis patients in our district. Methods: The subjects of this study involved 41 hemodialysis patients admitted to hemodialysis ward, Vali- Asr hospital. HBV, HDV, HIV, and HTLV1/2 infections were evaluated by enzyme-linked immunosorbent assay (ELISA) technique. Serum anti- HCV anti-body was measured using the 3rd generation of ELISA kit. HCV Viremia was evaluated in all patients using RT-PCR technique. Results: HCV infection was not observed in none of patients by ELISA technique; however RT-PCR technique demonstrated HCV viremia in one (2.43%) patient. HBsAg was detected in 4(9.75%) patients, and one (2.43%) was Anti HTLV 1/2 positive; none of patients were HDV or HIV positive. Conclusion: HCV infection is less common than HBV infection in our patients. ELISA technique can not demonstrate all hemodialysis patients with HCV infection, For this reason it is requirement to evaluate this group of patients for HCV infection using RT-PC technique. DOI: http://dx.doi.org/10.3329/bjms.v13i1.13903 Bangladesh Journal of Medical Science Vol. 13 No. 01 January2014: 36-39
Highlights
Hepatitis C virus (HCV) infection is the most common chronic blood borne infection in the world1
It is estimated that 5-20% of HCV– infected patients will develop cirrhosis, 1-4% of whom will annually develop hepatocellular carcinoma2,3
Hepatitis C is the major cause of liver disease among patients with chronic renal failure4
Summary
Hepatitis C virus (HCV) infection is the most common chronic blood borne infection in the world. Patients with chronic renal failure are at higher risk of acquiring blood borne infections including viral hepatitis and HIV infection. The routine evaluation of hemodialysis patients for blood borne infections including HCV infection is recommended 5-6. This study was performed to evaluate the prevalence of Hepatitis C virus (HCV) infection as well as HBV, HDV, HTLV I/II, and HIV infection in hemodialysis patients in our district. HBV, HDV, HIV, and HTLV1/2 infections were evaluated by enzyme-linked immunosorbent assay (ELISA) technique. Results: HCV infection was not observed in none of patients by ELISA technique; RT-PCR technique demonstrated HCV viremia in one (2.43%) patient. ELISA technique can not demonstrate all hemodialysis patients with HCV infection, For this reason it is requirement to evaluate this group of patients for HCV infection using RT-PC technique
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