Abstract
The prevalence of HBV DNA among seronegative blood donations in China has not been studied extensively on a nationwide scale. The aim of this study was to analyse the prevalence, trend, distributions, and serological characteristics of HBV DNA positive/seronegative blood donations. We collected HBV test data from all blood banks of China from 2010 to 2015 and performed supplemental serological tests and quantitative detection of HBV DNA of the seronegative/HBV DNA positive blood donations. We analysed the prevalence of HBV DNA among seronegative blood donations screened by varying nucleotide acid test (NAT) reagents. The analysis results showed that a total of 20,084,187 seronegative blood donations were screened by NAT from 2010 to 2015 in China. The average frequency of HBV DNA among seronegative blood donations was 1/1482, but there has been a steady increase from 1/1861 in 2011 to 1/1269 in 2015. The geographical distribution of seronegative and HBV DNA positive blood donations was roughly consistent with that of HBsAg. The most common serological pattern was HBeAb and HBcAb positive. In conclusion, our study offeres fundamental data of seronegative and HBV DNA positive blood donations throughout China.
Highlights
Hepatitis B virus (HBV) infection remains a significant public health concern worldwide, with more than 350 million chronic HBV carriers around the world[1]
There is still a risk of transmitted HBV (TTHBV) infection via blood donated by HBV surface antigens (HBsAg) negative donors who are in the window period (WP) or chronic occult HBV infection (OBI) stage[5,6]
20,084,187 seronegative blood donations were admitted for blood Nucleic acid test (NAT) screening in blood banks in China
Summary
Hepatitis B virus (HBV) infection remains a significant public health concern worldwide, with more than 350 million chronic HBV carriers around the world[1]. The risk of transfusion transmitted HBV (TTHBV) is a challenge for blood safety in China. There is still a risk of TTHBV infection via blood donated by HBsAg negative donors who are in the window period (WP) or chronic occult HBV infection (OBI) stage[5,6]. Nucleic acid test (NAT) analysis of blood donors has been reported to detect potential infectious HBV in the WP and OBI stages, which provides additional safety to blood transfusion[8]. In 2010, the Ministry of Health of the People’s Republic of China started a NAT screening program for HBV, hepatitis C virus, and human immunodeficiency virus infection in several blood banks. To date, no study has reported on the frequency of HBV DNA positivity among seronegative blood donors throughout China. This study is aimed to: (1) calculate the prevalence of HBV DNA positive/ seronegative blood donors, (2) evaluate the trends in the prevalence of HBV DNA positive/seronegative blood donors over the last six years, (3) analyse the geographical distribution of the prevalence within the country, (4) calculate the percentage of total detection number and prevalence of HBV DNA positive/seronegative of NAT reagents, and (5) assess the serological characteristics of HBV DNA positive/seronegative blood donations
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