Abstract
Prevalence of Glucose 6 Phosphate Dehydrogenase deficiency in Eastern India, a Study from a Tertiary Care Hospital
Highlights
Comparison of Glucose 6 phosphate dehydrogenase (G6PD) activity between the Tribal and Non-tribal population showed that 60% of G6PD deficient cases belong to the Tribal community while the rest 40 % belong to the Non-tribal community (Table 5)
The occupational groups did not show any difference in the incidence of Glucose 6 phosphate dehydrogenase deficiency
The highest frequency (27.94%) of Glucose 6 phosphate dehydrogenase enzyme deficiency has been reported from Surat, Gujarat
Summary
Glucose 6 phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive hereditary disease characterized by abnormally low levels of G6PD, a metabolic enzyme involved in the pentose phosphate pathway, which is especially important in erythrocyte metabolism. G6PD deficiency is the most common human enzyme defect being present in more than 400 million people worldwide. All humans have the Glucose 6 phosphate dehydrogenase gene. Some people are born with a mutation of the Glucose 6 phosphate dehydrogenase gene. Most of these individuals are asymptomatic but may exhibit non-immune hemolytic anemia, even severe anemia in response to exposure to certain environmental triggers, most commonly, infection or exposure to certain foods like fava beans (favism), medications or chemicals [10]
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