Abstract
Due to intrinsically developed resistance in Pseudomonas aeruginosa, with extended-spectrum β-lactamase (ESBL) and metallo β-lactamase (MBL)-producing genes, such P. aeruginosa isolates have become a major threat to public health. Therefore, in this study, the synthesis of MBL and the prevalence of ESBL were observed phenotypically in P. aeruginosa using the DDST test. Seventy-six out of 120 strains of P. aeruginosa were obtained from animal milk and human sputum, blood, respiratory tract, and abscess. A total of 76 isolates (51.31%) synthesized ESBLs, 48.6% produced MBL, and 68.6% produced AmpC. The genotypic prevalence of MBL and ESBL for bla TEM-1 and bla IMP-1 was 20.12 and 17.8%, respectively. The results demonstrated a considerable prevalence of MBL and ESBL among P. aeruginosa isolates, with different enzyme variants detected in each sample. The data was significant for the P values less than 0.05.
Published Version
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