Abstract
Invasive bacterial diseases (IBD) cause significant morbidity and mortality which leads to enormous health suffering and economic frustration in Bangladesh especially in people with resource poor region. The prevalence of IBD may vary even in different regions in a country. To understand the prevalence of etiologic agents causing IBD and determining their response to commonly used standard antibiotics we conducted a retrospective cross sectional study in rural town of Bangladesh on patient attended for blood culture with IBD sign-symptoms in well reputed microbiology lab. We considered IBD patients (118) of all age groups (0-85 years) both gender (male 54% and female 46%). 25% (30) blood culture of all IBD patients found bacterial growth positive including contaminant Staphylococcus sp. (10). The isolated IBD etiologic agents are S. aureus (10), Salmonella sp. (5), Salmonella Paratyphi (1), E. coli (2), Shigella sp. (1), Pseudomonas sp. (1). We could have retrieved antibiotic susceptibility testing data of five isolates including S. aureus (1), Salmonella sp. (2), Salmonella Paratyphi (1), Pseudomonas sp. (1); which showed except Salmonella sp. all isolates are sensitive to tested commonly used standard antibiotics. Two non typhoidal Salmonella sp. showed intermediate sensitivity to ciprofloxacin (5 ìg) which indicate reconsideration of choosing non typhoidal Salomonella sp. infection with ciprofloxacin (5 ìg). As it is a retrospective, not well organized cross sectional study; these findings may not represent the entire actual scenario of IBD in the region. As a consequence, a well organizing and adequately powered study must need to be conducted
 Asian J. Med. Biol. Res. December 2018, 4(4): 330-336
Highlights
Invasive bacterial diseases (IBD) are major cause of morbidity and mortality
Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Streptococcus agalactiae, Streptococcus pyogenes, Staphylococcus aureus, Salmonella species, Listeria species, and Escherichia coli are major bacteria involved in invasive infections in children especially in immunocompetent children (Nam and Lee, 1998; Lee et al, 2005)
S. aureus are involved in diverse range of clinical complications including asymptomatic colonization, skin and soft tissue infection and bone and joint infections
Summary
Invasive bacterial diseases (IBD) are major cause of morbidity and mortality. In developing countries like Bangladesh IBD in children under 5 years is the significant public health problem. Invasive bacterial infection can be defined as the detection of bacteria in the normally sterile body fluids such as blood, cerebrospinal fluid (CSF), joint fluid, pleural fluid, pericardial fluid, bone aspirate, or a deep tissue abscess (Schuchat et al, 2001). Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Streptococcus agalactiae, Streptococcus pyogenes, Staphylococcus aureus, Salmonella species, Listeria species, and Escherichia coli are major bacteria involved in invasive infections in children especially in immunocompetent children (Nam and Lee, 1998; Lee et al, 2005). Pneumonia is the leading cause of mortality among the children under 5 years which globally
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