PREVALENCE OF ELEVATED AST, ALT, ALP IN TYPE 2 DIABETES MELLITUS

Abstract

Background:Type 2 diabetes mellitus (T2DM) is a major public health concern affecting millions of people worldwide. The relationship between liver enzymes and T2DM has been reported in limited studies. The aim of this study is to evaluate the prevalence of elevated liver enzymes in T2DM. Methods: A total of 200 individuals (100 diabetic and 100 nondiabetic) were enrolled in the study. Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP) activities were measured in serum collected from them. T2DM was dened as fasting blood glucose (FBG) ≥126 mg/dLor self-reported recent use of insulin or antidiabetic medications. Results:Among the participants, 63% in T2DM and 30% in the non-diabetic group had at least one or more elevated liver enzymes in serum. The mean concentrations of serum AST, ALT and ALP were signicantly higher in the T2DM group compared to the non-diabetes group, suggesting high prevalence of elevated liver enzymes in the T2DM. Conclusions: A high prevalence of elevated liver enzymes was observed in subjects having T2DM than in non-diabetics. More studies of this nature should be carried out in developing countries to get proper insights into the importance of assessing liver enzymes in T2DM.