Prevalence of diabetic peripheral neuropathy in Iran: a systematic review and meta-analysis.

Sahar Sobhani,Hamid Asayesh,Shirin Djalalinia,Mohammad Parvaresh Masoud,Morteza Mansourian,Seyed Masoud Arzaghi,Hossein Ansari,Aziz Rezapoor,Farshad Sharifi,Hamid Reza Baradaran,Mostafa Qorbani

doi:10.1186/s40200-014-0097-y

Abstract

Diabetic peripheral neuropathy (DPN) is an important microvascular complication of diabetes mellitus (DM). It is a major contributor to foot ulceration and lower limb amputation in persons with DM and have also a significant negative effect on patient's quality of life. This meta-analysis reviews prevalence of DPN among patients with type 1 and 2 DM in Iran. Using PubMed and NLM Gateway (for MEDLINE), Institute of Scientific Information (ISI), and SCOPUS as the main international electronic data sources, and Iranmedex, Irandoc, and Scientific Information Database (SID), as the main domestic databases with systematic search capability, we systematically searched surveys, papers, and reports on the prevalence of DPN (between January 1991 to February 2013). Heterogeneity of reported prevalence’s between studies was assessed by the Chi-square-based Q test and due to heterogeneity; overall prevalence of DPN was estimated using random-effect meta-analysis model. We found 304 records; from them a total of 21 studies comprising 5540 diabetic patients were included. The prevalence of diabetic neuropathy (reported) from 16% to 87%. In overall the prevalence of DPN estimated 53% (95% CI: 41-65) by using random-effect. This study show that the prevalence of DPN seems very high among the population with diabetes in Iran and more than half of the patients with DM has any type of diabetic neuropathy.

Highlights

One of the major complications of diabetes mellitus (DM) is represented by the diabetic peripheral neuropathy (DPN)
Search strategy The relevant empirical literature was identified by searching several electronic databases: Main domestic databases; Iran-Medex, Scientific Information Database (SID), Irandoc, and in international databases; PubMed and NLM Gateway, Institute of Scientific Information (ISI), and SCOPUS, between January 1991 to February 2013
Definition Diabetic neuropathy is a nerve disorder caused by diabetes mellitus

Summary

Introduction

One of the major complications of diabetes mellitus (DM) is represented by the diabetic peripheral neuropathy (DPN). Neuropathy is the most common complication and greatest source of morbidity and mortality in diabetes patients. A DPN account for more hospital admissions than all other diabetic complications combined and is responsible for 50 – 75% of non-traumatic amputations [2,3]. Considering the priority of problem and its increasing co-morbid complication, there is an undeniable need to prepare primary data for more awareness of stakeholders and better policy recommendations [8]. To address this issue, we should provide comprehensive scientific evidence that support policy actions, programs monitoring, and interventions evaluation [9]

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Conclusion