Prevalence of congenital cleft lip and/or palate in Guangdong province, 2011-2015

Abstract

Objective To analyze the prevalence of cleft lip and/or cleft palate between 2011 and 2015 in Guangdong province. Methods The study involves birth defects monitor records of mothers and infants (28 weeks gestation to 7 days after childbirth) between 2011 and 2015 from monitoring network hospitals in Guangdong province. Key information of mothers of the children with cleft lip and/or clip palate was carried out. The data were analysed using descriptive statistics method, such as Chi-square, orderly classification regression, and composition ratio. Results A total of 1 203 800 medical records were screened and the birth prevalence of all cleft types was 13.82/10 000 for 2011-2015. The case detection rates were 15.81/10 000, 14.00/10 000, 9.02/10 000, 15.81/10 000 and 11.00/10 000 from 2011 to 2015 respectively, without obvious trend. There was no clear trend among the years, and had no statistic significant differences in monthly incidence (χ2= 128.34, P= 0.403) , the April and September had the lowest and highest of total Cleft Lip and/or Palate incidence respectively. A comparison of gender differences revealed that males had a greater risk (χ2= 32.74, P<0.0001) , and the distribution of cleft lip, cleft lip and palate, or cleft palate had a statistic significant differences (χ2= 52.78, P= 0.0012) . The constituent ratio of cleft palate, cleft lip, and cleft lip and palate were 27.94%, 25.54% and 46.51% respectively. Conclusions It′s necessary to offer health education about cleft lip or palate to the general population, and a wider range of risk factors can lead to a greater understanding of the etiology. Key words: Cleft lip; Cleft palate; Cleft Lip and Palate