Abstract
BackgroundThe improper handling of a peripherally inserted central catheter (PICC) in newborns (NBs) may result in mechanical and infectious complications.AimThe aim of this systematic review (SR) is to estimate the prevalence of complications associated with the use of PICC in NBs.MethodsWe will utilize PubMed, Embase, CENTRAL, Web of Science, Scopus, Cochrane Library, CINAHL, and Google Scholar for the databases search. There will be no restrictions on the search for languages, and observational studies will be selected wherein the prevalence rate of complications associated with the use of PICC in NBs has been presented or can be calculated. The systematic review will follow the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Two reviewers will independently select studies and assess their eligibility using predefined criteria. Using standardized forms, two other reviewers will independently extract data from each included study, and the random-effects pooled prevalence will be calculated in the meta-analysis with the respective 95% confidence intervals. The methodological quality of the studies will be assessed using the modified Newcastle-Ottawa Scale. Review Manager V.5.3.5 will be used for the qualitative and quantitative synthesis. A protocol was developed and published on PROSPERO (Registration number CRD42020211983).Expected resultsThis SR will show the prevalence of complications caused by the inadequate management of PICC in NBs, which is information considered important for clinical practice improvement.
Highlights
The insertion of peripherally inserted central catheters (PICC) is common in neonatal intensive care units (NICU) in term newborns (NBs) and premature infants receiving venous therapies with vesicant and irritating drugs and parenteral nutrition
Previous studies have identified risk factors for complications associated with the use of PICC in NBs, including gestational age (GA), catheter insertion location, catheter tip location, and catheter dwell time, especially when it is installed for greater than 35 days, a factor associated with an increased catheter-related bloodstream infection [1, 4]
Knowledge about the actual prevalence of complications resulting from the use of PICC is essential for clinical practice in NICU and may allow the adoption of strategies that reduce those that are more serious, which can lead to the death of NBs
Summary
We will utilize PubMed, Embase, CENTRAL, Web of Science, Scopus, Cochrane Library, CINAHL, and Google Scholar for the databases search. There will be no restrictions on the search for languages, and observational studies will be selected wherein the prevalence rate of complications associated with the use of PICC in NBs has been presented or can be calculated. Using standardized forms, two other reviewers will independently extract data from each included study, and the random-effects pooled prevalence will be calculated in the meta-analysis with the respective 95% confidence intervals. Prevalence of PICC complications in newborns: A systematic review protocol role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This SR will show the prevalence of complications caused by the inadequate management of PICC in NBs, which is information considered important for clinical practice improvement
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