Prevalence of chlamydia trachomatis infection among reproductive age women in sub Saharan Africa: a systematic review and meta-analysis

Siraj Hussen,Endale Tadesse,Demelash Wachamo,Zemenu Yohannes

doi:10.1186/s12879-018-3477-y

Abstract

BackgroundChlamydia trachomatis is the most common curable sexual transmitted bacterial infection in the world, including Sub-Saharan Africa. There is nil systematic review and meta-analysis on Chlamydia trachomatis infection in Sub-Saharan Africa among reproductive age women. Therefore, this study was carried out to determine the pooled prevalence of chlamydia trachomatis infection in Sub-Saharan Africa among reproductive age women.MethodsA comprehensive literature search was conducted from biomedical data bases: Medline, PubMed, EMBASE, Google scholar, HINARI and Cochrane Library using a special index search terms (medical subject headings (MeSH), title and abstract. The Cochrane Q test and I2 statistics was used to test heterogeneity and publication bias was assessed using Begg’s and Egger’s tests. Results were presented in tables, figures and funnel plot. Data were pooled in a meta-analysis using a random effects model.ResultsTwenty-four studies were included in this meta–analysis. There was a high level of heterogeneity among studies. The pooled prevalence of Chlamydia trachomatis infection in Sub-Saharan Africa among reproductive age women was 7.8% (95% CI: 5.6–10.6).ConclusionThis review showed that Chlamydia trachomatis infection is high in Sub-Saharan Africa among reproductive age group women. This evidence suggests that governmental and non-governmental organization shall give attention for primary prevention of this infection. Likewise, in resource limited countries policy makers, stakeholders and health care providers’ due attention for Chlamydia trachomatis specific and rapid diagnostic test, treatment in any medical out and in patient clinics for reproductive age women.

Highlights

Chlamydia trachomatis is the most common curable sexual transmitted bacterial infection in the world, including Sub-Saharan Africa
The World Health Organization (WHO) estimated that 50 million women were newly infected with Chlamydia trachomatis worldwide, of which 34 million were in Sub-Saharan Africa and South/
WHO estimated that, the incidence of Chlamydia trachomatis is high in sub-Saharan Africa, which is more than 10 million new infection annually [2]

Summary

Introduction

Chlamydia trachomatis is the most common curable sexual transmitted bacterial infection in the world, including Sub-Saharan Africa. There is nil systematic review and meta-analysis on Chlamydia trachomatis infection in Sub-Saharan Africa among reproductive age women. This study was carried out to determine the pooled prevalence of chlamydia trachomatis infection in Sub-Saharan Africa among reproductive age women. Chlamydia trachomatis is the major public health concern across the globe,and the main cause of sexual transmitted infections throughout the world, especially Sub-Saharan Africa [1]. The World Health Organization (WHO) estimated that 50 million women were newly infected with Chlamydia trachomatis worldwide, of which 34 million were in Sub-Saharan Africa and South/. Chlamydia trachomatis is the most common curable sexual transmitted bacterial infection in the world, with an estimated 4–5 million new cases each year [6]. Chlamydial infection in Hussen et al BMC Infectious Diseases (2018) 18:596 women show that different clinical manifestations and associated disease like: cervicitis,endometritis, salpingitis, pelvic inflammatory disease, infertility, preterm rupture of membranes, perihepatitis, while most of women do not get medical care, because more than three forth of women are commonly asymptomatic [9].Untreated Chlamydial infection cause up to 40% of pelvic inflammatory disease cases, one in four of these will result in infertility [10]

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Discussion

Conclusion